- 1807: Thomas Green Clemson, IV, future namesake of the university, born in Philadelphia, Pennsylvania, the son of Thomas Green Clemson, III, and Elizabeth Baker.
- 1859: The Blue Ridge Railroad Company makes its first issue of stock. A full sheet represented $1,000 of stock value.
- 1894: The Southern Railway Company is formed by J.P. Morgan & Company, New York Bankers, consolidating a number of bankrupt Southern rail lines, including the Richmond and Danville Railroad, which serves Calhoun, South Carolina.
- 1895: Date after which Prof. Henry Aubrey Strode receives no salary, though he will still remain on the mathematics faculty until 1896, at which time he will be asked by the board of trustees to resign.
- 1965: The School of Education is created. Dr. Harold F. Landrith is named new dean. (The Tiger, Friday, September 3, 1965, Volume LIX, Number 2, page 1).
- 1979: President Robert C. Edwards retires after 21 years at Clemson's helm. Bill Atchley takes office as the ninth Clemson president.
- 1985: Dean Walter T. Cox becomes the tenth president of Clemson University, replacing Bill Atchley, whose resignation becomes effective this date. He will serve 249 days in this capacity. (Wunder, John R., "A Good Sport: Walter Thompson Cox, 1985-1986", McKale, Donald M., editor, "Tradition: A History of the Presidency of Clemson University", Mercer University Press, Macon, Georgia, 1988, ISBN 0-86554-296-1, page 257.)
- 1987: Former Clemson President Bill Lee Atchley assumes the presidency of the University of the Pacific in California.
- 1991: The Atlantic Coast Conference expands to nine members as Florida State is admitted.
- 1995: Robert Weston Smith, "Wolfman Jack", dies at home in Belvedere, North Carolina.
- 2004: The Atlantic Coast Conference expands to 11 members, with the addition of the University of Miami and Virginia Polytechnic Institute & State University.
- 2005: Boston College becomes the twelfth member of the Atlantic Coast Conference.
- 2008: A smoking ban in public spaces goes into effect in the City of Clemson this date. Penalty is a $100 fine. Private clubs are not affected by the new ordinance.
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