- Henry Simms Hartzog, future Clemson president, is born into a family of prosperous planters at Georges Creek, near Olar in Bamberg county, South Carolina. (Kohl, Michael F., "A Youthful Administrator: Henry Simms Hartzog, 1893-1897", "Tradition: A History of the Presidency of Clemson University", McKale, Donald M., editor, Mercer University Press, Macon, Georgia, 1988, ISBN 0-86554-296-1, page 54.)
- January 11: Paul Thomas Brodie, future Professor of Mathematics and Civil Engineering at Clemson Agricultural College, is born near Leesville, South Carolina, this date.
- April 2: President Andrew Johnson declares the rebellion officially ended. (Lander, Jr., Ernest McPherson, "A History of South Carolina, 1865-1960", The University of South Carolina Press, Chapel Hill, 1960, page 9.)
- Patrick Hues Mell matriculates at the University of Georgia.
- November 24: "At a meeting of the Agricultural Society of Pendleton, S. C., held on the 24th of November, 1866, in its Hall at Pendleton, Anderson District, Hon. R. F. Simpson, Col. W. A. Hayne and Hon. Thomas G. Clemson were appointed a Committee to appeal to their fellow-men for aid, to found an institution for educating our people in the sciences, to the end that our agriculture be improved, our worn, impoverished lands be recuperated, and the great natural resources of the South developed. ...
- This upper region of South Carolina would appear, above all others, adapted for the location of such an institution. For the picturesque, this mountain region will vie with Switzerland. For health and climate, if not excelled, if equalled, by any portion of North America.
- Donations of funds, books, apparatus, are earnestly solicited, and considering the purposes of the Society, it is hoped that all public carriers, railroads and express companies will exempt packages from charges.
- A record will be carefully kept and handed down to posterity, accrediting the donors for their respective contributions. Agricultural and other Societies, and those who may have influence, would confer obligations upon the Society by acting as agents in collecting and forwarding contributions.
- Editors of newspapers, and other publishers, are respectfully requested to give insertions to this appeal, that it may meet the eye of all who feel an interest in the advancement of civilization in this ruined, but still a part of our common country.
- Letters and contributions to be directed to Hon. Thos. G. Clemson, L. L. D., Chairman of Committee, Pendleton, Anderson District, South Carolina." (Circular, November 1866, Special Collections, Strom Thurmond Institute, Clemson University.)
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