Events that occurred in 1964 in Clemson history
- I-85's South Carolina portion is completed, the first interstate highway finished in the state.
- January: The Georgia Institute of Technology Engineers withdraw from the Southeastern Conference to become an independent school.
- March: Governor Donald Russell signs bill changing the name of the school from The Clemson Agricultural College of South Carolina to Clemson University.
- The Clemson Players are founded.
- April 4: Beatlemania! All of the top five songs in Billboard magazine's rankings are by The Beatles, the only time in history that one artist or group ever achieved this. They are: "Can't Buy Me Love", ""Twist and Shout", "She Loves You", "I Want To Hold Your Hand" and "Please Please Me". (Bronson, Fred, "The Billboard Book of Number One Hits", Billboard Publications, New York, 1985, ISBN 0-8230-7522-2, page 145.)
- September 15: The United States Navy commissions the USS John C. Calhoun, SSBN-630, the fleet's 26th missile-firing submarine. (Cook, Harriet Heffner, "John C. Calhoun - the Man", The R.L. Bryan Co., Columbia, S.C., 1965, Library of Congress Card No. 65-19779, page 2.)
- September 18: Jonny Quest debuts at 7:30 pm Eastern on ABC.
- September 19: Clemson blanks Furman, 28-0, in Death Valley. The Tigers and the Paladins will not meet again on the gridiron until September 10, 1988.
- September 26: Clemson road trips to Raleigh, loses to N.C. State, 0-9.
- October 3: In road game in Atlanta, Georgia Tech downs the Tigers, 7-14.
- October 10: In Athens, Georgia defeats Clemson, 7-19.
- October 17: Clemson plays at Wake Forest, beats the Demon Deacons, 21-2.
- October 24: The Tigers take on the Texas Christian Horned Frogs in Texas, losing, 10-14.
- October 31: Clemson defeats Virginia, 29-7, in Death Valley.
- November 7: North Carolina skunks the Tigers, 0-29, in Memorial Stadium.
- November 14: Clemson travels to College Park, where Maryland wins handily, 0-34.
- November 20: The Tigers are defeated by the Gamecocks, 3-7, in Clemson. Tigers go 3-7, 2-4 in conference, for seventh place in the ACC.