Oconee County is located just to the West of Clemson and is abutted by the States of North Carolina to the North and Georgia to the West. The county seat is Walhalla which takes its name from mythology. Much of Oconee County is bordered by Lakes Hartwell and Keowee with Sumter National Forest land in in the mountainous North. The Pickens-Oconee line runs along the western edge of Clemson and the University.
The Clemson Campus and the neighborhoods to its south and southeast were part of Oconee County until the county line was redrawn on February 20, 1967, trading ten square miles of land on the southern border for wilderness along the northern border of Pickens County and Oconee County.