- 1900: At Vaughan, Mississippi, Illinois Central passenger train No. 1, the Cannonball, crashes into the rear of freight train No. 83 which is fouling the main line out of a siding at 3:52 a.m. on the Water Valley District of the Mississippi Division. Engineer of 2-6-0 Mogul No. 382, John Luther "Casey" Jones, the only fatality, is found to be solely at fault by the ensuing investigation for having disregarded safety warnings behind the stalled train. The accident spawns the vastly popular "Ballad of Casey Jones" by roundhouse worker and friend of the deceased, Wallace Saunders, and the root theme for a Grateful Dead song titled "Casey Jones".
- 1924: The worst tornado in Anderson history leaves eight dead, hundreds homeless, and countless injured.
- 1955: New York-based consulting firm Cresap, McCormick, and Paget releases four-volume "Clemson Agricultural College Survey of Administrative Management", critiquing the college structure and making many recommendations, including realigning executive functions, eliminating mandantory military training, and opening the doors to women students. (McKale, Donald M., editor, "Tradition: A History of the Presidency of Clemson University", Mercer University Press, Macon, Georgia, 1988, ISBN 0-86554-296-1, page 189.)
- 1967: The Rev. Martin Luther King, Jr. speaks to a rally of 3,500 at Greenville Memorial Auditorium, giving the local civil rights movement a boost.
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