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  • The town of Andersonville, South Carolina, located at the confluence of the Seneca River and the Tugloo River, is inundated when a freshet carries away the cotton and wool mills, and the cotton gin. This is the second such flood, the first in 1840 having also wiped out the mills and gin, which were rebuilt. Andersonville, founded in 1801, fades away with the onset of the War Between the States after it fails to attract a rail line and river trade declines.(Klosky, Beth Ann, "The Pendleton Legacy", Sandlapper Press, Inc., Columbia, South Carolina, 1971, Library of Congress card number 73-143043, ISBN 0-87844-005-4, pages 77-79). This should be distinguished from Andersonville, Georgia, site of a notorious prison-of-war camp.
  • August 3: Rowing is the first intercollegiate sport in the United States with the first regatta occurring between Harvard and Yale on this date in 1852. Clemson officials announce on July 11, 1997, that women's rowing will be added as a varsity sport. ("Clemson: Where The Tigers Play", by Sam Blackman, Bob Bradley and Chuck Kriese, Sports Publishing, L.L.C., 2001, page 150).
  • November 5: The American Society of Civil Engineers and Architects is formed in New York City.
  • December 16: The Blue Ridge Railroad is chartered to build a line from Edgefield via Abbeville, Anderson, and Walhalla in South Carolina; Rabun Gap in Georgia; and down the Little Tennessee River in North Carolina and Tennessee to Knoxville. Only the section between Belton, Anderson and West Union, and later, Walhalla, is ever completed.

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1851 The 1850's 1853