- 1862: Mark Bernard Hardin is appointed Major of Artillery in the Provisional Army of the Confederate States, and assigned to duty as Commander of the 18th Virginia Battalion of Heavy Artillery, in the defences of Richmond. He continues in this capacity, being in charge of a considerable portion of the line, until the evacuation of Richmond.
- 1875: William S. Morrison graduates from Wofford College, with honors. (The Oconeean 1904, Volume Two, page 15.)
- 1886: Thomas Green Clemson, IV, is given an honorary degree from the South Carolina College.
- 1895: Clemson's first graduate, Charles Carter Newman, son of J. S. Newman, the college's first professor of agriculture, receives his degree. He had already completed his sophomore year of studies at Auburn where his father had taught before coming to Clemson. (Bryan, Wright, "Clemson: An Informal History of the University 1889-1979", The R. L. Bryan Company, Columbia, South Carolina, 1979, ISBN 0-934870-01-2, page 51.)
- 1902: After twice tendering his resignation, President Henry Simms Hartzog departs Clemson for the University of Arkansas. Widespread drinking is reported at the June commencement, a fall-out of low morale on campus following the first-ever student walk-out, in April and May.
- 1903: Alonzo Sheck Shealy, who entered Iowa State College at Amer, March 1900, after graduation from Clemson, receives his degree as Doctor of Veterinary Medicine.
- 1909: Clemson College was reported to be considering building an electric railway from Calhoun, the location of the Southern Railway depot, through Clemson to Cherry Station on the Blue Ridge Railroad in a June 1909 newsbrief appearing in the Electric Railway Journal. Walter Merritt Riggs wrote a rebuttal for the next issue which declared that the trustees had considered the idea, but had agreed that it was not practical. Considering the size of the town involved (Cherry Station, at best, had four nearby families), the line would have seen reasonable use only when the college semesters began and ended. (Source: Palmetto Traction - Electric Railways of South Carolina by Thomas Fetters, 1978, Forty Fort, Pennsylvania, no ISBN. - Fetters is Class of 1961, with a BS in Chemical Engineering.)
- 1912: President Walter Merritt Riggs informs Senator and Trustee Benjamin Tillman that dining steward August "Shorty" Schilletter "must have knocked down between five and eight thousand dollars a year". At this time, Riggs' salary is $3,500 per annum.
- 1915: "At the annual meeting of the Alumni Association in June, the Tiger was unanimously made the official organ of the Alumni Association. We want every old Clemson man to keep in touch with the college and know what is being done. Subscribe to the Tiger and you will know all the news around the college. We need your help, without it, the paper can not be made what it should be." (The Tiger, 21 September 1915, Volume XI, Number 1, page 2.)
- 1919: Month through which the operation of the Students' Army Training Corps was envisioned, but with quick end to the Great War on November 11, 1918, only five and half weeks after the S. A. T. C. was begun, all members of the military training program are mustered out by December 20.
- 1933: U.S. Highway 29, the "Main Street of the South", is completed between Washington and New Orleans, and passes through Anderson.
- 2001: Former Football Coach Charlie Pell commits suicide after battle with lung cancer.
- 2006: Work begins on a new transmission tower to replace the WSBF antenna that failed after a lightning strike in December 2005.